解密心-腸軸：產製丁酸的細菌可促進心臟修復

Dr. Patrick C.H. Hsieh’s team at the Institute of Biomedical Sciences, Academia Sinica uncovered a pivotal gut-heart axis in post-myocardial infarction (MI) cardiac repair. Employing human clinical samples, nonhuman primate disease models, and mouse cardiac injury models, they revealed the significance of butyrate-producing bacteria, particularly in synthesizing β-hydroxybutyrate post-injury. This breakthrough offers precision medication targets for MI through gut microbiota adjustments. The study, titled "Gut Butyrate-Producers Confer Post-Infarction Cardiac Protection", published in Nature Communications on Nov 9th, involved collaborators from National Cheng Kung University, China Medical University Hospital, Far Eastern Memorial Hospital, and the University of Wisconsin-Madison (UW-Madison). Funding was provided by the National Science and Technology Council, Academia Sinica, National Health Research Institutes, and UW-Madison.

Gut butyrate-producers confer post-infarction cardiac protection
Chen HC, Liu YW, Chang KC, Wu YW, Chen YM, Chao YK, You MY, Lundy DJ, Lin CJ, Hsieh ML, Cheng YC, Prajnamitra RP, Lin PJ, Ruan SC, Chen DHK, Shih ESC, Chen KW, Chang SS, Chang CMC, Puntney R, Moy AW, Cheng YY, Chien HY, Lee JJ, Wu DC, Hwang MJ, Coonen J, Hacker TA, Yen CLE, Rey FE, Kamp TJ & Hsieh PCH
Nat Commun 14, 7249 (2023). Doi: 10.1038/s41467-023-43167-5

圖說： 心肌梗塞後，青春雙歧桿菌、副血鏈球菌與病毒性蓖麻桿菌的增加會促進丁酸與3-羥基丁酸之生產，並藉由血液循環送到心臟進而達到調節心肌梗塞後之心臟修復。(圖片藉由Biorender產生)
新聞聯絡人：
謝清河 (中央研究院生物醫學科學研究所特聘研究員)
(Tel) 02-2789-9170，phsieh@ibms.sinica.edu.tw
論文網址 (Nature Communications)